This research considers the feasibility and possible nature of a case definition of work-related stress that is suitable for application in a variety of stakeholder domains. The most important of these, for this research, is that of the epidemiological domain. The overall issue is important in two different contexts. First, it is needed in occupational health epidemiology as the basis for surveillance, and for monitoring the effectiveness of interventions. Second, it is of obvious importance in determining the award of compensation in civil litigation, employee liability insurance and industrial injury claims.